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Beyond Tumors: Reduced Survival Linked to Pathogenic PIK3CA and TP53 Post-Zygotic Variants in the Uninvolved Breast Tissue of Recurrent Cancer Patients

2025-08-06

Abstract excerpt

<title>Abstract</title> <p>Background Histologically normal mammary tissue from breast cancer patients can harbor significant genetic alterations that could precede visible tumor development and influence disease progression. Methods Whole-exome sequencing was performed on 408 samples from 77 breast cancer patients with poor prognosis, 49 patients recruited without prognosis-based selection, and 15 individuals un...

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Literature Corpus work
cd1b3a78-8463-5954-8a27-3f258afe21e0
DOI
10.21203/rs.3.rs-7293078/v1
Open publication

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Beyond Tumors: Reduced Survival Linked to Pathogenic PIK3CA and TP53 Post-Zygotic Variants in the Uninvolved Breast Tissue of Recurrent Cancer PatientsDOI 10.21203/rs.3.rs-7293078/v1
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