Article

Distinct genomic and immunologic tumor evolution in germline <i>TP53-</i> driven breast cancers

2024-04-07

Abstract excerpt

Pathogenic germline TP53 alterations cause Li-Fraumeni Syndrome (LFS), and breast cancer is the most common cancer in LFS females. We performed first of its kind multimodal analysis of LFS breast cancer (LFS-BC) compared to sporadic premenopausal BC. Nearly all LFS-BC underwent biallelic loss of TP53 with no recurrent oncogenic variants except ERBB2 (HER2) amplification. Compared to sporadic BC, in situ and in...

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Identifiers and source

Literature Corpus work: c8366d63-eaa5-5bf5-86e6-2b6410ba7b03
DOI: 10.1101/2024.04.03.588009

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