Article

Inherited <i>BRCA1</i> epimutation as a novel cause of breast and ovarian cancer

2018-01-15

Abstract excerpt

<h4>Background</h4> Pathogenic variants in BRCA1 or BRCA2 are identified in ~20% of families with multiple individuals with early-onset breast/ovarian cancer. Extensive searches for additional highly penetrant genes or alternative mutational mechanisms altering BRCA1/2 have not explained the missing heritability. For the first time, we report transgenerational epigenetic silencing of BRCA1 due to promoter hyp...

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Literature Corpus work: c3096099-4915-5836-b174-c901d05c8f2e
DOI: 10.1101/246934

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