Beyond tumors: uninvolved breast tissue of breast cancer patients with adverse prognoses is enriched for pathogenic PIK3CA and TP53 post-zygotic variants.

doi:10.1186/s12885-026-16086-z

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Beyond tumors: uninvolved breast tissue of breast cancer patients with adverse prognoses is enriched for pathogenic PIK3CA and TP53 post-zygotic variants.

BMC cancer - 30 Apr 2026

Andreou Maria, Chojnowska Katarzyna, Filipowicz Natalia, Horbacz Monika, Madanecki Piotr, Duzowska Katarzyna, Ławrynowicz Urszula, Davies Hanna, Bruhn-Olszewska Bożena, Koszyński Mikołaj, Drężek-Chyła Kinga, Jaśkiewicz Maciej, Jąkalski Marcin, Kostecka Anna, Drzewiecka-Kłysz Marta, Nowikiewicz Magdalena, Las-Jankowska Manuela, Bała Dariusz, Hoffman Jacek, Śrutek Ewa, Jankowski Michał, Jankau Jerzy, Hodorowicz-Zaniewska Diana, Szpor Joanna, Szylberg Łukasz, Zegarski Wojciech, Nowikiewicz Tomasz, Buckley Patrick G, Tiemann-Boege Irene, Mieczkowski Jakub, Koczkowska Magdalena, Dumanski Jan P, Piotrowski Arkadiusz

Abstract excerpt

BACKGROUND: Histologically normal mammary tissue from breast cancer patients can harbor significant genetic alterations that could precede visible tumor development and influence disease progression. METHODS: Whole-exome sequencing was performed on 408 samples from 77 breast cancer patients with poor prognosis, 49 patients recruited without prognosis-based selection, and 15 individuals undergoing...

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Identifiers

PMID: 42063004
DOI: 10.1186/s12885-026-16086-z
PMCID: PMC13274006

Genes

TP53
PIK3CA
AKT1
PTEN
TBX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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