Article

Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR7

2019-12-16

Abstract excerpt

A lysosomal transmembrane protein SLC29A3 transports nucleosides from lysosomes to the cytoplasm. Loss-of-function mutations of the SLC29A3 gene cause lysosomal nucleoside storage in monocyte/macrophages, leading to their accumulation called histiocytosis in humans and mice. Little is known, however, about a mechanism behind nucleoside-dependent histiocytosis. TLR7, an innate immune sensors for single stranded RNA...

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Literature Corpus work: adbaba77-0927-51bf-9b12-fe472b7e5967
DOI: 10.1101/2019.12.16.877357

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