Article
Sensing soluble uric acid by Naip1-Nlrp3 platform
2020-05-15
Abstract excerpt
<h4>Summary</h4> The immune system can recognize microbes and sterile tissue damage. Among the damage-associated molecular patterns (DAMPs), uric acid is considered a major component which can trigger inflammation. It represents a breakpoint in the evolutionary history of humans as our ancestors lost the uricase gene, the enzyme responsible for its cleavage. High soluble uric acid (sUA) concentration is able to i...
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Identifiers and source
- Literature Corpus work
- 360faa38-0056-57c4-9d15-3ab62846a838
- DOI
- 10.1101/2020.05.15.077644