Article

The lysosomal carrier SLC29A3 supports anti-bacterial signaling and promotes autophagy by activating TRPML1 in mouse dendritic cells

2025-06-17

Abstract excerpt

The solute carrier (SLC)29A3 exports nucleosides from lysosomes into the cytosol, maintaining solute homeostasis and providing metabolic intermediates for cellular processes. Loss-of-function mutations in SLC29A3 cause H syndrome, characterized by hyperinflammation and immunodeficiency. While dysfunctions in various cell types contribute to H syndrome and to SLC29A3 deficiency in mice, the mechanisms driving hyper...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 12c7f324-dcb3-54a2-8409-01e24ae54ffc
DOI: 10.1101/2025.06.11.659112

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The lysosomal carrier SLC29A3 supports anti-bacterial signaling and promotes autophagy by activating TRPML1 in mouse dendritic cellsDOI 10.1101/2025.06.11.659112Read

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders.Semantic proximity Read

Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR7Semantic proximity Read

TLR7/8 stress response drives histiocytosis in SLC29A3 disordersSemantic proximity Read

A non-canonical autophagy-dependent role of the ATG16L1T300A variant in urothelial vesicular trafficking and uropathogenic Escherichia coli persistenceSemantic proximity Read

Loss of function of ENT3 drives histiocytosis and inflammation through TLR-MAPK signaling.Semantic proximity Read

Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor traffickingSemantic proximity Read

Carboxylesterase 1 directs the metabolic profile of dendritic cells to a reduced inflammatory phenotype.Semantic proximity Read

Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells.Semantic proximity Read

Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonistsSemantic proximity Read

SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease.Semantic proximity Read

Novel gain-of-function mutation in dysferlin causes vesicle trafficking defect and IL-1 mediated autoinflammationSemantic proximity Read

Whole-exome sequencing identifies mutations in the nucleoside transporter gene SLC29A3 in dysosteosclerosis, a form of osteopetrosis.Semantic proximity Read