Article
Equilibrative Nucleoside Transporter 3 Regulates T Cell Homeostasis by Coordinating Lysosomal Function with Nucleoside Availability.
Cell reports - 22 May 2018
Wei Chin-Wen, Lee Chia-Ying, Lee Ding-Jin, Chu Chang-Feng, Wang Ju-Chu, Wang Tien-Chiao, Jane Wann-Neng, Chang Zee-Fen, Leu Chuen-Miin, Dzhagalov Ivan L, Hsu Chia-Lin
Abstract excerpt
T cells are a versatile immune cell population responding to challenges by differentiation and proliferation followed by contraction and memory formation. Dynamic metabolic reprogramming is essential for T cells to meet the biosynthetic needs and the reutilization of biomolecules, processes that require active participation of metabolite transporters. Here, we show that equilibrative nucleoside transporter 3...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.