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Article

Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes.

The Journal of clinical investigation - 1 Oct 2020

Pfefferlé Marc, Ingoglia Giada, Schaer Christian A, Yalamanoglu Ayla, Buzzi Raphael, Dubach Irina L, Tan Ge, López-Cano Emilio Y, Schulthess Nadja, Hansen Kerstin, Humar Rok, Schaer Dominik J, Vallelian Florence

Abstract excerpt

During hemolysis, macrophages in the liver phagocytose damaged erythrocytes to prevent the toxic effects of cell-free hemoglobin and heme. It remains unclear how this homeostatic process modulates phagocyte functions in inflammatory diseases. Using a genetic mouse model of spherocytosis and single-cell RNA sequencing, we found that erythrophagocytosis skewed liver macrophages into an antiinflammatory phenotype...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32663195
DOI: 10.1172/JCI137282
PMCID: PMC7524492

Genes

CD40
NFE2L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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