Article

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Endosomal Sensing by Dendritic Cells in Psoriasis

2020-03-11

Abstract excerpt

<h4>SUMMARY</h4> The mechanisms underlying tissue-specific chronic inflammation are elusive. Here we report that mice lacking Protein Phosphatase 6 in keratinocytes are predisposed to psoriasis-like skin inflammation, with an inordinate urea cycle and enhanced oxidative phosphorylation that supports hyperproliferation. This phenotype is mediated by increased Arginase-1 production resulting from CCAAT/enhancer-bin...

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Literature Corpus work: 64b266f7-27e1-5547-bf4e-b01a67815b23
DOI: 10.1101/2020.03.09.984658

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