Article

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

2022-10-27

Abstract excerpt

SLC29A3, also known as ENT3, is a lysosomal transmembrane protein that transports nucleosides from the lysosomes to the cytoplasm 1 . Loss-of-function mutations in SLC29A3 cause lysosomal nucleoside storage and histiocytosis: phagocyte accumulation in multiple organs 2,3 . However, little is known about the mechanism through which lysosomal nucleoside storage drives histiocytosis. Herein, histiocytosis in Slc2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4dd8eef-2365-53f4-8368-bbb3107b3a0f
DOI: 10.1101/2022.10.27.513971

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TLR7/8 stress response drives histiocytosis in SLC29A3 disordersDOI 10.1101/2022.10.27.513971Read

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders.Semantic proximity Read

Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR7Semantic proximity Read

Loss of function of ENT3 drives histiocytosis and inflammation through TLR-MAPK signaling.Semantic proximity Read

The lysosomal carrier SLC29A3 supports anti-bacterial signaling and promotes autophagy by activating TRPML1 in mouse dendritic cellsSemantic proximity Read

Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disordersSemantic proximity Read

Lysosomes cell autonomously regulate myeloid cell states and immune responsesSemantic proximity Read

Equilibrative Nucleoside Transporter 3 Regulates T Cell Homeostasis by Coordinating Lysosomal Function with Nucleoside Availability.Semantic proximity Read

Endosome dysfunction leads to gain-of-function TLR7 and human lupusSemantic proximity Read

The lysosomal disease caused by mutant VPS33ASemantic proximity Read

Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathwaySemantic proximity Read

Multinucleation resets human macrophages for specialized functions at the expense of mononuclear phagocyte identitySemantic proximity Read

Secretion of the human Toll-like receptor 3 ectodomain is affected by single nucleotide polymorphisms and regulated by Unc93b1.Semantic proximity Read