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Article

Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration

1 Mar 2016

Abstract excerpt

A zebrafish genetic screen for determinants of susceptibility to Mycobacterium marinum identified a hypersusceptible mutant deficient in lysosomal cysteine cathepsins that manifests hallmarks of human lysosomal storage diseases. Under homeostatic conditions, mutant macrophages accumulate undigested lysosomal material, which disrupts endocytic recycling and impairs their migration to, and thus engulfment of, dying...

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PMID: 27015311
DOI: 10.1016/j.cell.2016.02.034

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