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Article

Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors.

Nature communications - 7 Oct 2021

Gavin Amanda L, Huang Deli, Blane Tanya R, Thinnes Therese C, Murakami Yusuke, Fukui Ryutaro, Miyake Kensuke, Nemazee David

Abstract excerpt

Phospholipase D3 (PLD3) and PLD4 polymorphisms have been associated with several important inflammatory diseases. Here, we show that PLD3 and PLD4 digest ssRNA in addition to ssDNA as reported previously. Moreover, Pld3-/-Pld4-/- mice accumulate small ssRNAs and develop spontaneous fatal hemophagocytic lymphohistiocytosis (HLH) characterized by inflammatory liver damage and overproduction of Interferon (IFN)-γ....

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Identifiers

PMID: 34620855
DOI: 10.1038/s41467-021-26150-w
PMCID: PMC8497607

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