Article
TLR7/8 stress response drives histiocytosis in SLC29A3 disorders.
The Journal of experimental medicine - 4 Sept 2023
Shibata Takuma, Sato Ryota, Taoka Masato, Saitoh Shin-Ichiroh, Komine Mayumi, Yamaguchi Kiyoshi, Goyama Susumu, Motoi Yuji, Kitaura Jiro, Izawa Kumi, Yamauchi Yoshio, Tsukamoto Yumiko, Ichinohe Takeshi, Fujita Etsuko, Hiranuma Ryosuke, Fukui Ryutaro, Furukawa Yoichi, Kitamura Toshio, Takai Toshiyuki, Tojo Arinobu, Ohtsuki Mamitaro, Ohto Umeharu, Shimizu Toshiyuki, Ozawa Manabu, Yoshida Nobuaki, Isobe Toshiaki, Latz Eicke, Mukai Kojiro, Taguchi Tomohiko, Hemmi Hiroaki, Akira Shizuo, Miyake Kensuke
Abstract excerpt
Loss-of-function mutations in the lysosomal nucleoside transporter SLC29A3 cause lysosomal nucleoside storage and histiocytosis: phagocyte accumulation in multiple organs. However, little is known about the mechanism by which lysosomal nucleoside storage drives histiocytosis. Herein, histiocytosis in Slc29a3-/- mice was shown to depend on Toll-like receptor 7 (TLR7), which senses a combination of nucleosides and...
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