Back to search

Article

Gene editing of putative cAMP and Ca <sup>2+</sup> -regulated proteins using an efficient cloning-free CRISPR/Cas9 system in <i>Trypanosoma cruzi</i>

2023-07-10

Abstract excerpt

<h4>ABSTRACT</h4> Trypanosoma cruzi , the agent of Chagas disease, must adapt to a diversity of environmental conditions that it faces during its life cycle. The adaptation to these changes is mediated by signaling pathways that coordinate the cellular responses to the new environmental settings. Cyclic AMP (cAMP) and Calcium (Ca 2+ ) signaling pathways regulate critical cellular processes in this parasite, such...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ad85fa52-5f8a-5ce7-847d-1c85cdf1df9b
DOI
10.1101/2023.07.09.548290
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Gene editing of putative cAMP and Ca <sup>2+</sup> -regulated proteins using an efficient cloning-free CRISPR/Cas9 system in <i>Trypanosoma cruzi</i>DOI 10.1101/2023.07.09.548290
Gene editing of putative c AMP and Ca2+‐regulated proteins using an efficient cloning‐free CRISPR /Cas9 system in Trypanosoma cruziSemantic proximity
TcCARP3 modulates compartmentalized cAMP signals involved in osmoregulation, infection of mammalian cells, and colonization of the triatomine vector in the human pathogen <i>Trypanosoma cruzi</i>Semantic proximity
MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca 2+ Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruziSemantic proximity
Cyclic AMP compartmentalization drives signal specificity to control vector colonization and mammalian host infection by American trypanosomesSemantic proximity
Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in <i>T. brucei</i>Semantic proximity
State‐of‐the‐art CRISPR /Cas9 Technology for Genome Editing in TrypanosomatidsSemantic proximity
Genome Editing by <scp>CRISPR</scp>/Cas9: A Game Change in the Genetic Manipulation of ProtistsSemantic proximity
<p class="MDPI13authornames" style="margin-bottom: 12.0pt;">Pleiotropic Effects on Tachyzoite and Host Cell Proteomes in Knock-Out Clones of the Open Reading Frames 297720 and 319730 Constitutively Expressed in <em>T. gondii</em> ShSp1 TachyzoitesSemantic proximity
CRISPR-Cas9-Mediated Single-Gene and Gene Family Disruption in Trypanosoma cruziSemantic proximity
Evaluation of the basic functions of six calcium-dependent protein kinases in Toxoplasma gondii using CRISPR-Cas9 system.Semantic proximity
The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference!Semantic proximity
Glycosomal phosphoenolpyruvate carboxykinase CRISPR/Cas9-deletion and its role in <i>Trypanosoma cruzi</i> metacyclogenesis and infectivity in mammalian hostSemantic proximity
Select a neighboring publication to make it the new centre.