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MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca 2+ Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi

6 May 2019

Abstract excerpt

Trypanosoma cruzi is the etiologic agent of Chagas disease and belongs to the early-branching eukaryotic supergroup Excavata. Its mitochondrial calcium uniporter (MCU) subunit shares similarity with the animal ortholog that was important to discover its encoding gene. In animal cells, the MICU1 and MICU2 proteins act as Ca 2+ sensors and gatekeepers of the MCU, preventing Ca 2+ uptake under resting conditions and...

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Identifiers

PMID: 31064825
DOI: 10.1128/mbio.00348-19

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