Article

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in <i>T. brucei</i>

2023-03-17

Abstract excerpt

Cyclic AMP signalling in trypanosomes differs from most eukaryotes due to absence of known cAMP effectors and cAMP independence of PKA. We have previously identified four genes from a genome-wide RNAi screen for resistance to the cAMP phosphodiesterase (PDE) inhibitor NPD-001. The genes were named cAMP Response Protein (CARP) 1 through 4. Here, we report an additional six CARP candidate genes from the original sam...

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Literature Corpus work: 01edb3d4-86b7-5d27-b52c-0423db29a87e
DOI: 10.1101/2023.03.14.532707

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