Article

Cyclic AMP compartmentalization drives signal specificity to control vector colonization and mammalian host infection by American trypanosomes

2025-12-08

Abstract excerpt

Cyclic AMP (cAMP) signaling is crucial for environmental sensing and response to stress conditions in trypanosomatids. However, the mechanisms driving the specificity of cAMP signals remain poorly understood in these protozoan parasites. We recently identified two putative cAMP microdomains in Trypanosoma cruzi , the causative agent of Chagas disease. Here, considering the localization of three phosphodiesterases...

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Literature Corpus work: 7ca7a3c0-8f0e-5286-926e-d0f46c8ce652
DOI: 10.64898/2025.12.04.692279

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