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Glycosomal phosphoenolpyruvate carboxykinase CRISPR/Cas9-deletion and its role in <i>Trypanosoma cruzi</i> metacyclogenesis and infectivity in mammalian host

2024-12-21

Abstract excerpt

<h4>ABSTRACT</h4> Trypanosoma cruzi , the causative agent of Chagas disease, possesses glycosomes - unique organelles that house key metabolic enzymes, several of which are promising therapeutic targets. Among them, phosphoenolpyruvate carboxykinase (PEPCK) plays a central role in succinic fermentation, the main pathway for NAD + regeneration within the organelle. Using CRISPR/Cas9 editing, PEPCK gene was disrup...

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Literature Corpus work
72bfd627-c408-5c6a-8d86-9b1bdd63e069
DOI
10.1101/2024.12.20.629751
Open publication

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