Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISPR-Cas9-Mediated Single-Gene and Gene Family Disruption in Trypanosoma cruzi

30 Dec 2014

Abstract excerpt

UNLABELLED: Trypanosoma cruzi is a protozoan parasite of humans and animals, affecting 10 to 20 million people and innumerable animals, primarily in the Americas. Despite being the largest cause of infection-induced heart disease worldwide, even among the neglected tropical diseases (NTDs) T. cruzi is considered one of the least well understood and understudied. The genetic complexity of T. cruzi as well as the...

Topics

Join the communities discussing this publication.

Congenital heart defects research
CRISPR and Genetic Engineering
Trypanosoma species research and implications

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25550322
DOI: 10.1128/mbio.02097-14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISPR-Cas9-Mediated Single-Gene and Gene Family Disruption in Trypanosoma cruziPMID 25550322Read ↗

State‐of‐the‐art CRISPR /Cas9 Technology for Genome Editing in TrypanosomatidsSemantic proximity Read ↗

Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 RibonucleoproteinsSemantic proximity Read ↗

Efficient Genome Engineering of Toxoplasma gondii Using CRISPR/Cas9Semantic proximity Read ↗

First efficient CRISPR-Cas9-mediated genome editing in L eishmania parasitesSemantic proximity Read ↗

Optimizing Systems for Cas9 Expression in Toxoplasma gondiiSemantic proximity Read ↗

A limitation lifted: A conditional knockdown system reveals essential roles for Polo-like kinase and Aurora kinase 1 in Trypanosoma cruzi cell divisionSemantic proximity Read ↗

Genome Editing by <scp>CRISPR</scp>/Cas9: A Game Change in the Genetic Manipulation of ProtistsSemantic proximity Read ↗

Application of the CRISPR/Cas9 gene editing technique to research on functional genomes of parasitesSemantic proximity Read ↗

Evaluation of high efficiency gene knockout strategies for Trypanosoma cruziSemantic proximity Read ↗

Efficient Editing of Malaria Parasite Genome Using the CRISPR/Cas9 SystemSemantic proximity Read ↗

CRISPR-Cas9-Mediated Genome Editing in Leishmania donovaniSemantic proximity Read ↗

Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.