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Gene editing of putative c AMP and Ca2+‐regulated proteins using an efficient cloning‐free CRISPR /Cas9 system in Trypanosoma cruzi

19 Sept 2023

Abstract excerpt

Abstract Trypanosoma cruzi, the agent of Chagas disease, must adapt to a diversity of environmental conditions that it faces during its life cycle. The adaptation to these changes is mediated by signaling pathways that coordinate the cellular responses to the new environmental settings. Cyclic AMP (cAMP) and Calcium (Ca2+) signaling pathways regulate critical cellular processes in this parasite, such as...

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PMID: 37724511
DOI: 10.1111/jeu.12999

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