Article

A common pattern of DNase-I footprinting throughout the human mtDNA unveils clues for a chromatin-like organization

2017-09-23

Abstract excerpt

Human mitochondrial DNA (mtDNA) is believed to lack chromatin and histones. Instead, it is coated solely by the transcription factor TFAM, which binds the mtDNA without sequence specificity and packs it into a bacterial-like nucleoid in a dose-dependent fashion. We asked whether mtDNA packaging is more regulated than once thought. As a first step to address this question, we analyzed mtDNA DNase-I-seq experiments...

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Literature Corpus work: ad52bca8-cd52-5817-984a-9957302d7a31
DOI: 10.1101/193037

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