Article

UV irradiation alters TFAM binding specificity and compaction of DNA

2024-10-24

Abstract excerpt

Mitochondria lack nucleotide excision repair; however, mitochondrial DNA (mtDNA) is resistant to mutation accumulation following DNA damage. These observations suggest additional damage sensing or protection mechanisms. Transcription Factor A, Mitochondrial (TFAM) compacts mtDNA into nucleoids and binds differentially to certain forms of DNA damage. As such, TFAM has emerged as a candidate for protecting mtDNA or...

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Literature Corpus work: caca5c86-56ad-5653-8e7a-40e6bd22b050
DOI: 10.1101/2024.10.24.620005

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