Article

Initiation of mtDNA transcription is followed by pausing, and diverge across human cell types and during evolution

2016-05-18

Abstract excerpt

Mitochondrial DNA (mtDNA) genes are long known to be co-transcribed in polycistrones, yet it remains impossible to study nascent mtDNA transcripts quantitatively in vivo using existing tools. To this end we used deep sequencing (GRO-seq and PRO-seq) and analyzed nascent mtDNA-encoded RNA transcripts in diverse human cell lines and metazoan organisms. Surprisingly, accurate detection of human mtDNA transcription in...

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Literature Corpus work: 6c7e88af-2ce5-5467-a614-28c0aaeb1d89
DOI: 10.1101/054031

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