Replication and Transcription of Human Mitochondrial DNA.

doi:10.1146/annurev-biochem-052621-092014

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Article

Replication and Transcription of Human Mitochondrial DNA.

Annual review of biochemistry - 1 Aug 2024

Falkenberg Maria, Larsson Nils-Göran, Gustafsson Claes M

Abstract excerpt

Mammalian mitochondrial DNA (mtDNA) is replicated and transcribed by phage-like DNA and RNA polymerases, and our understanding of these processes has progressed substantially over the last several decades. Molecular mechanisms have been elucidated by biochemistry and structural biology and essential in vivo roles established by cell biology and mouse genetics. Single molecules of mtDNA are packaged by...

Topics

Humans
DNA, Mitochondrial
DNA Replication
Transcription, Genetic
Animals
Mitochondria
Mitochondrial Diseases
Transcription Factors
Mutation
Mitochondrial Proteins

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Identifiers

PMID: 38594940
DOI: 10.1146/annurev-biochem-052621-092014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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