Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Initiation of mtDNA transcription is followed by pausing, and diverges across human cell types and during evolution.

Genome research - 1 Mar 2017

Blumberg Amit, Rice Edward J, Kundaje Anshul, Danko Charles G, Mishmar Dan

Abstract excerpt

Mitochondrial DNA (mtDNA) genes are long known to be cotranscribed in polycistrones, yet it remains impossible to study nascent mtDNA transcripts quantitatively in vivo using existing tools. To this end, we used deep sequencing (GRO-seq and PRO-seq) and analyzed nascent mtDNA-encoded RNA transcripts in diverse human cell lines and metazoan organisms. Surprisingly, accurate detection of human mtDNA transcription...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Mitochondrial
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Invertebrates

Share to Organ Specificity

Share to Primates

Share to Rodentia

Share to Transcription Initiation Site

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 28049628
DOI: 10.1101/gr.209924.116
PMCID: PMC5340964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Initiation of mtDNA transcription is followed by pausing, and diverges across human cell types and during evolution.PMID 28049628Read ↗

Initiation of mtDNA transcription is followed by pausing, and diverge across human cell types and during evolutionSemantic proximity Read ↗

A common pattern of DNase-I footprinting throughout the human mtDNA unveils clues for a chromatin-like organizationSemantic proximity Read ↗

Large heterogeneity of mitochondrial DNA transcription and initiation of replication exposed by single-cell imagingSemantic proximity Read ↗

RNA-DNA differences in human mitochondria restore ancestral form of 16S ribosomal RNA.Semantic proximity Read ↗

The Genomic Architecture of Human DNA Replication OriginsSemantic proximity Read ↗

Replication and Transcription of Human Mitochondrial DNA.Semantic proximity Read ↗

Precise annotation of human, chimpanzee, rhesus macaque and mouse mitochondrial genomes using 5’ and 3’ end small RNAsSemantic proximity Read ↗

CpG methylation patterns of human mitochondrial DNASemantic proximity Read ↗

Ancient mtDNA genetic variants modulate mtDNA transcription and replication.Semantic proximity Read ↗

An overview of mammalian mitochondrial DNA replication mechanisms.Semantic proximity Read ↗

Probability-based sequence comparison finds pre-eutherian nuclear mitochondrial DNA segments in mammalian genomesSemantic proximity Read ↗

Ancient Out-of-Africa Mitochondrial DNA Variants Associate with Distinct Mitochondrial Gene Expression Patterns.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.