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Article

Mammalian transcription factor A is a core component of the mitochondrial transcription machinery.

Proceedings of the National Academy of Sciences of the United States of America - 9 Oct 2012

Shi Yonghong, Dierckx Anke, Wanrooij Paulina H, Wanrooij Sjoerd, Larsson Nils-Göran, Wilhelmsson L Marcus, Falkenberg Maria, Gustafsson Claes M

Abstract excerpt

Transcription factor A (TFAM) functions as a DNA packaging factor in mammalian mitochondria. TFAM also binds sequence-specifically to sites immediately upstream of mitochondrial promoters, but there are conflicting data regarding its role as a core component of the mitochondrial transcription machinery. We here demonstrate that TFAM is required for transcription in mitochondrial extracts as well as in a...

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Identifiers

PMID: 23012404
DOI: 10.1073/pnas.1119738109
PMCID: PMC3478657

Genes

TFAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mammalian transcription factor A is a core component of the mitochondrial transcription machinery.PMID 23012404Read ↗

TFAM organizes DNA into compact higher order structuresSemantic proximity Read ↗

Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA.Semantic proximity Read ↗

The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiation.Semantic proximity Read ↗

A common pattern of DNase-I footprinting throughout the human mtDNA unveils clues for a chromatin-like organizationSemantic proximity Read ↗

UV irradiation alters TFAM binding specificity and compaction of DNASemantic proximity Read ↗

Disease causing mutation (P178L) in mitochondrial transcription factor A results in impaired mitochondrial transcription initiation.Semantic proximity Read ↗

Nucleic acid sequence determinants of transcriptional pausing by human mitochondrial RNA polymerase (POLRMT)Semantic proximity Read ↗

Replication and Transcription of Human Mitochondrial DNA.Semantic proximity Read ↗

Interaction of human mitochondrial transcription factor A in mitochondria: its involvement in the dynamics of mitochondrial DNA nucleoids.Semantic proximity Read ↗

The strictly aerobic yeast Yarrowia lipolytica tolerates loss of a mitochondrial DNA-packaging protein.Semantic proximity Read ↗

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid.Semantic proximity Read ↗

The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels.Semantic proximity Read ↗

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