Article

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells

2025-10-06

Abstract excerpt

The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information about extracellular nucleic acids. Here, we provide evidence that oxidized mitochondrial DNA is tethered to the surface of select mammalian cells through cell surface proteins and heparan sulfate proteoglycans. We dem...

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Literature Corpus work: a5859717-d5ab-5d7f-be0c-3ccc2fcb4eec
DOI: 10.1101/2025.10.05.680464

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