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Article

Interleukin 11 expression causes murine inflammatory bowel disease

2019-09-05

Abstract excerpt

Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor. Here we examined the effects of SMC-specific, conditional expression of murine IL11 in a transgenic mouse ( Il11 SMC ). Within days of transgene activation, Il11 SMC mice developed loose stools and progr...

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Literature Corpus work
ad032d06-4e0c-5622-8590-3ae3d2bc7dd8
DOI
10.1101/756098
Open publication

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Interleukin 11 expression causes murine inflammatory bowel diseaseDOI 10.1101/756098
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