Article

Cellular complexity and crosstalk in murine TNF-dependent ileitis: Different fibroblast subsets propel spatially defined ileal inflammation through TNFR1 signalling

2023-09-29

Abstract excerpt

Crohn’s disease represents a persistent inflammatory disorder primarily affecting the terminal ileum. Through the application of single-cell RNA sequencing, we unveil the intricate cellular complexities within murine TNF-dependent ileitis, developing in Tnf ΔARE mice. Detailed immune cell analysis highlights B cell expansion, T cell effector reprogramming, and macrophage lineage shifts during inflammation. Focusi...

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Literature Corpus work: 50d50c49-89a9-5538-abf1-bbd93277db6a
DOI: 10.1101/2023.09.29.560107

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