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Article

Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice.

PloS one - 1 Jan 2020

Lim Wei-Wen, Ng Benjamin, Widjaja Anissa, Xie Chen, Su Liping, Ko Nicole, Lim Sze-Yun, Kwek Xiu-Yi, Lim Stella, Cook Stuart Alexander, Schafer Sebastian

Abstract excerpt

Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor. Here we examined the effects of SMC-specific, conditional expression of murine IL11 in a transgenic mouse (Il11SMC). Within days of transgene activation, Il11SMC mice developed loose stools and...

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Identifiers

PMID: 31917819
DOI: 10.1371/journal.pone.0227505
PMCID: PMC6952089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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