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Article

IL11 stimulates IL33 expression and proinflammatory fibroblast activation

2022-07-08

Abstract excerpt

Interleukin 11 (IL11) is upregulated in inflammatory conditions where it is believed to have anti-inflammatory activity. However, recent studies suggest instead that IL11 may promote inflammation, via the stroma. Here, we assessed whether IL11 is pro- or anti-inflammatory in fibroblasts. Primary cultures of human kidney, lung or skin fibroblasts were stimulated with IL11 that resulted in transient STAT3 phosphoryl...

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Identifiers and source

Literature Corpus work
97b110de-bafe-5973-9f75-2a29e55890cb
DOI
10.1101/2022.07.08.499236
Open publication

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IL11 stimulates IL33 expression and proinflammatory fibroblast activationDOI 10.1101/2022.07.08.499236
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