Article

Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability

2024-11-15

Abstract excerpt

<h4>Summary</h4> The disproportionate expansion of telencephalic structures during human evolution involved tradeoffs that imposed greater connectivity and metabolic demands on midbrain dopaminergic neurons. Despite the central role of dopaminergic neurons in human-enriched disorders, molecular specializations associated with human-specific features and vulnerabilities of the dopaminergic system remain unexplored...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: acf1592b-4e4e-5634-8fbd-5feaf218615c
DOI: 10.1101/2024.11.14.623592

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and VulnerabilityDOI 10.1101/2024.11.14.623592Read

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoidsSemantic proximity Read

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoidsSemantic proximity Read

Establishing Cerebral Organoids as Models of Human-Specific Brain EvolutionSemantic proximity Read

BrainSTEM: A multi-resolution fetal brain atlas to assess the fidelity of human midbrain culturesSemantic proximity Read

A human developmental and adult brain atlas benchmarks dopaminergic stem cell models and cell therapy candidatesSemantic proximity Read

Brainstem organoids from human pluripotent stem cells contain neural crest populationSemantic proximity Read

Orthogonal Modes of Gene Expression Evolution Shape Human Neocortical Development and Disease VulnerabilitySemantic proximity Read

Human-chimpanzee tetraploid system defines mechanisms of species-specific neural gene regulationSemantic proximity Read

Induction of Dopaminergic Neurons for Neuronal Subtype-Specific Modeling of Psychiatric Disease RiskSemantic proximity Read

Reconstruction of the human nigrostriatal pathway in vitro reveals target-dependent dopamine neuron maturationSemantic proximity Read

Single-cell genomic atlas of great ape cerebral organoids uncovers human-specific features of brain developmentSemantic proximity Read

Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression.Semantic proximity Read