Article

Orthogonal Modes of Gene Expression Evolution Shape Human Neocortical Development and Disease Vulnerability

2025-12-12

Abstract excerpt

The neocortex is responsible for higher-order cognitive abilities such as language, abstract reasoning, and executive function—capacities that are particularly advanced in humans. To elucidate the molecular foundations of neocortical evolution in the human lineage, it is essential to examine how conserved gene repertoires have undergone expression changes relative to other mammals. The expression changes in conser...

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Literature Corpus work: e2da6aa3-3afe-5330-ba1a-4db4209d113f
DOI: 10.64898/2025.12.11.693619

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