Article

Reconstruction of the human nigrostriatal pathway in vitro reveals target-dependent dopamine neuron maturation

2025-12-26

Abstract excerpt

The human nigrostriatal pathway, comprising dopaminergic neurons in the ventral midbrain (vMB) projecting to the dorsolateral striatum, is essential for motor control and selectively vulnerable in Parkinson’s disease (PD). How this circuit assembles during development and how it degenerates under pathological conditions remains poorly understood in a human context and in vitro models capturing its long-range conn...

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Literature Corpus work: f6156e7a-66bf-5904-a58a-34fa8cb6177b
DOI: 10.64898/2025.12.23.696164

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