Article

Human-chimpanzee tetraploid system defines mechanisms of species-specific neural gene regulation

2025-03-31

Abstract excerpt

A major challenge in human evolutionary biology is to pinpoint genetic differences that underlie human-specific traits, such as increased neuron number and differences in cognitive behaviors. We used human-chimpanzee tetraploid cells to distinguish gene expression changes due to cis -acting sequence variants that change local gene regulation, from trans expression changes due to species differences in the cellul...

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Literature Corpus work: 025329d7-b8ec-5300-8f9d-0a0f370fa940
DOI: 10.1101/2025.03.31.646367

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