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Article

Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression.

American journal of human genetics - 3 Feb 2022

Zagare Alise, Barmpa Kyriaki, Smajic Semra, Smits Lisa M, Grzyb Kamil, Grünewald Anne, Skupin Alexander, Nickels Sarah L, Schwamborn Jens C

Abstract excerpt

Human brain organoid models that recapitulate the physiology and complexity of the human brain have a great potential for in vitro disease modeling, in particular for neurodegenerative diseases, such as Parkinson disease. In the present study, we compare single-cell RNA-sequencing data of human midbrain organoids to the developing human embryonic midbrain. We demonstrate that the in vitro model is comparable to...

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Identifiers

PMID: 35077669
DOI: 10.1016/j.ajhg.2021.12.009
PMCID: PMC8874228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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