Article

BrainSTEM: A multi-resolution fetal brain atlas to assess the fidelity of human midbrain cultures

2024-09-21

Abstract excerpt

Many midbrain dopaminergic neuron (mDA) differentiation protocols aimed at Parkinson’s disease (PD) modeling and cell replacement therapy have been developed. However, comprehensive evaluations of the transcriptomic fidelity of these protocols at the single-cell level against a common in vivo reference have been lacking. To this end, we constructed an integrated human fetal whole-brain atlas and a midbrain subatl...

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Literature Corpus work: 772e0e2c-55d2-5d00-8987-319af55ed271
DOI: 10.1101/2024.09.17.613274

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