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The Role of Apolipoprotein E Isoforms in Alzheimer’s Disease

12 Feb 2019

Abstract excerpt

Alzheimer's disease (AD), the most common type of dementia worldwide, is characterized by high levels of amyloid-β (Aβ) peptide and hyperphosphorylated tau protein. Genetically, the ɛ4 allele of apolipoprotein E (ApoE) has been established as the major risk factor for developing late-onset AD (LOAD), the most common form of the disease. Although the role ApoE plays in AD is still not completely understood, a...

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PMID: 30775980
DOI: 10.3233/jad-180740

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