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Article

Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.

Proceedings of the National Academy of Sciences of the United States of America - 7 Feb 2006

Cai Dongming, Zhong Minghao, Wang Runsheng, Netzer William J, Shields Dennis, Zheng Hui, Sisodia Sangram S, Foster David A, Gorelick Fred S, Xu Huaxi, Greengard Paul

Abstract excerpt

Presenilins (PS1/PS2) regulate proteolysis of beta-amyloid precursor protein (betaAPP) and affect its intracellular trafficking. Here, we demonstrate that a PS1-interacting protein, phospholipase D1 (PLD1), affects intracellular trafficking of betaAPP. Overexpression of PLD1 in PS1wt cells promot...

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Source

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Identifiers

PMID: 16449385
DOI: 10.1073/pnas.0510710103
PMCID: PMC1413666

Genes

PLD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16449385-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.PMID 16449385Read ↗

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