Phospholipase D3 contributes to Alzheimer’s disease risk via disruption of Aβ clearance and microglia response to amyloid plaques

Abstract excerpt

Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. AD is also the result of complex genetic architecture that can be leveraged to understand pathways central to disease processes. We have previously identified coding variants in the phospholipase D3 ( PLD3 ) gene that double the late-onset AD risk. However, the mechanism by which PLD3 i...

Topics

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• Amyloid beta-Peptides
• Amyloid beta-Protein Precursor
• Black or African American
• Exome
• Peptide Fragments
• Phospholipase D
• Protein Processing, Post-Translational
• Proteolysis

Identifiers and source

Literature Corpus work

85d8925b-9838-5fdf-9706-ab3e170226e2

DOI

10.1101/2022.01.31.22270175