Article

The effect of family history and polygenic risk scores on general and abdominal obesity in the Lifelines Cohort Study

2025-09-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Polygenic risk scores (PRSs) have recently become popular in predicting genetic susceptibility to common complex diseases. However, as PRSs only capture part of the genetic risk, imperfect prediction of outcomes is expected. Family history may capture additional genetic effects as well as those of shared family environment. Within-family design have the advantage to control...

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Literature Corpus work: ac9b8fda-90ad-536c-bd53-bb17991681c9
DOI: 10.1101/2025.09.22.25336364

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