Article

Systematic comparison of family history and polygenic risk across 24 common diseases

2022-07-07

Abstract excerpt

<h4>ABSTRACT</h4> Family history is the standard indirect measure of inherited susceptibility in clinical care, while polygenic risk scores (PRS) have more recently demonstrated potential for more directly capturing genetic risk in many diseases. No studies have systematically compared how these overlap and complement each other across common diseases. Within FinnGen (N=306,418), we leverage family relationships,...

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Literature Corpus work: 8ad843d6-69f9-5e67-ab5e-7a282efd5271
DOI: 10.1101/2022.07.06.22277333

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