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Article

Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk.

BMC medicine - 3 Feb 2026

Onyenobi Ebuka, Oyibo Knightess, Zhong Michael, Adebamowo Sally N

Abstract excerpt

BACKGROUND: Cardiometabolic diseases (CMD) are a leading cause of morbidity and mortality. While both family history (FH) and polygenic risk scores (PRS) are predictive of CMD risk, few studies have systematically evaluated their independent and joint effects. This study aimed to quantify the individual contributions of FH and PRS, as well as their combined impact on CMD risk. METHODS: We conducted an analysis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41629984
DOI: 10.1186/s12916-026-04666-6
PMCID: PMC12958630

Genes

FH
CAD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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