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Article

Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation.

PLoS genetics - 1 Feb 2016

Xia Charley, Amador Carmen, Huffman Jennifer, Trochet Holly, Campbell Archie, Porteous David, Hastie Nicholas D, Hayward Caroline, Vitart Veronique, Navarro Pau, Haley Chris S

Abstract excerpt

Genome-wide association studies have successfully identified thousands of loci for a range of human complex traits and diseases. The proportion of phenotypic variance explained by significant associations is, however, limited. Given the same dense SNP panels, mixed model analyses capture a greater proportion of phenotypic variance than single SNP analyses but the total is generally still less than the genetic...

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PMID: 26836320
DOI: 10.1371/journal.pgen.1005804
PMCID: PMC4737500

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Source receipt: pubmed, retrieved 7 Sept 2026.

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