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Article

Systematic comparison of family history and polygenic risk across 24 common diseases.

American journal of human genetics - 1 Dec 2022

Mars Nina, Lindbohm Joni V, Della Briotta Parolo Pietro, Widén Elisabeth, Kaprio Jaakko, Palotie Aarno, Ripatti Samuli

Abstract excerpt

Family history is the standard indirect measure of inherited susceptibility in clinical care, whereas polygenic risk scores (PRSs) have more recently demonstrated potential for more directly capturing genetic risk in many diseases. Few studies have systematically compared how these overlap and complement each other across common diseases. Within FinnGen (N = 306,418), we leverage family relationships, up to 50...

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Identifiers

PMID: 36347255
DOI: 10.1016/j.ajhg.2022.10.009
PMCID: PMC9748261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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