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Integrating Polygenic Scores and Family History for Type 2 Diabetes Prediction in an East Asian Population: Insights From the Taiwan Biobank.

Diabetes - 1 Mar 2026

Liao Wen-Ling, Cheng Chun-Wen, Chang Ya-Wen, Lin Mei-Chen, Cheng Chi-Fung, Tsai Shih-Feng, Hsu Chih-Cheng, Wang Shi-Heng

Abstract excerpt

Type 2 diabetes is a complex disease influenced by both genetic and environmental factors. Although polygenic risk scores (PRS) and family history (FH) are established predictors, their combined utility in East Asian populations remains unclear. In this study, we analyzed 111,899 unrelated participants from the Taiwan Biobank with linkage to nationwide health registry data. We constructed transancestry, East...

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PMID: 41467856
DOI: 10.2337/db25-0357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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