Article

Capturing additional genetic risk from family history for improved polygenic risk prediction

2022-01-07

Abstract excerpt

<h4>ABSTRACT</h4> Family history of complex traits may reflect transmitted rare pathogenic variants, intra-familial shared exposures to environmental and lifestyle factors, as well as a common genetic predisposition. We developed a latent factor model to quantify trait heritability in excess of that captured by a common variant-based polygenic risk score, but inferable from family history. For 941 children in the...

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Literature Corpus work: 44b19df4-7466-57a1-b1f1-cabcb1df75cf
DOI: 10.1101/2022.01.06.22268853

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