Article

Generative Design of Cell Type-Specific RNA Splicing Elements for Programmable Gene Regulation

2025-11-05

Abstract excerpt

Programmable control of gene expression in specific cell types is essential for both basic discovery and therapeutic intervention, yet current strategies lack scalability across diverse cellular contexts. Here, we introduce SPICE (Splicing Proportions In Cell types), an integrated experimental and computational framework that harnesses alternative RNA splicing as a programmable modality for cell type-specific gene...

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Literature Corpus work: ac615c7b-7fcf-5f72-8907-896343bcd851
DOI: 10.1101/2025.11.05.686847

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