Article

Generative modeling for RNA splicing prediction and design

2025-01-24

Abstract excerpt

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover new regulatory mechanisms and aid in therapeutics design. We introduce TrASPr+BOS, a generative AI model with Bayesian Optimization for predicting and designing RNA for tissue-specific splicing outcomes. TrASPr is a mu...

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Literature Corpus work: e38cf825-ca03-59d1-9978-9b4be2bdf5ba
DOI: 10.1101/2025.01.20.633986

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